Transient neonatal diabetes mellitus

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Transient neonatal diabetes mellitus
Autosomal dominant - en.svg
Transient neonatal diabetes mellitus is inherited in an autosomal dominant manner[1]
SpecialtyPediatrics Edit this on Wikidata

Transient neonatal diabetes mellitus (TNDM) is a form of diabetes mellitus presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).

Types[edit]

Type OMIM Gene Locus Description
TNDM1 601410 ZFP57, PLAGL1 6p22.1, 6p24.2
TNDM2 610374 ABCC8 11p15.1 Due to the mutations of the other subunit of the KATP channel, SUR1, which is encoded by the ABCC8 gene.[2]
TNDM3 610582 KCNJ11 11p15.1

Cause[edit]

This condition has to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).[citation needed]

The form on chromosome 6 can involve imprinting.[3]

[4]

Diagnosis[edit]

Management[edit]

See also[edit]

References[edit]

  1. ^ "OMIM Entry - # 610582 - DIABETES MELLITUS, TRANSIENT NEONATAL, 3". omim.org. Retrieved 12 September 2017.
  2. ^ de Wet H, Proks P, Lafond M, et al. (May 2008). "A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes". EMBO Rep. 9 (7): 648–54. doi:10.1038/embor.2008.71. PMC 2475326. PMID 18497752.
  3. ^ Raphaël Scharfmann (2007). Development of the Pancreas and Neonatal Diabetes. Karger Publishers. pp. 113–. ISBN 978-3-8055-8385-5. Retrieved 10 November 2010.
  4. ^ "Other Forms (MODY, LADA, Neonatal)". www.DiabetesCare.net. DiabetesCare.net. Retrieved 20 November 2014.

Further reading[edit]

External links[edit]

Classification
External resources