SCN4B

SCN4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MZ2, 4MZ3
Identifiers
Aliases	SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDs	OMIM: 608256 MGI: 2687406 HomoloGene: 18384 GeneCards: SCN4B
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 118,133,377 bp End 118,152,888 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.2 Start 45,138,395 bp End 45,154,152 bp
Gene ontology Molecular function • sodium channel regulator activity • ion channel binding • sodium channel activity • voltage-gated ion channel activity • voltage-gated sodium channel activity involved in cardiac muscle cell action potential • voltage-gated sodium channel activity Cellular component • voltage-gated sodium channel complex • integral component of membrane • membrane • intercalated disc • intrinsic component of plasma membrane • plasma membrane Biological process • cardiac muscle contraction • sodium ion transmembrane transport • sodium ion transport • regulation of ion transmembrane transport • cardiac muscle cell action potential involved in contraction • ion transport • regulation of sodium ion transmembrane transporter activity • positive regulation of sodium ion transport • AV node cell action potential • regulation of heart rate by cardiac conduction • membrane depolarization during cardiac muscle cell action potential • regulation of ventricular cardiac muscle cell membrane repolarization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6330	399548
Ensembl	ENSG00000177098	ENSMUSG00000046480
UniProt	Q8IWT1	Q7M729
RefSeq (mRNA)	NM_001142348 NM_001142349 NM_174934	NM_001013390
RefSeq (protein)	NP_001135820 NP_001135821 NP_777594	NP_001013408
Location (UCSC)	Chr 11: 118.13 – 118.15 Mb	Chr 9: 45.14 – 45.15 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels. The protein is encoded by the SCN4B gene. Mutations in the SCN4B are associated with long QT syndrome.

SCN4B might additionally function as a cell adhesion molecule.

See also

• Sodium channel

References

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• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577–85. PMID 12930796.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit". Pflügers Arch. 457 (6): 1253–63. doi:10.1007/s00424-008-0600-8. PMC 6207185. PMID 18941776.
• Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.